Replacement substance P reduces cardiac fibrosis in monkeys with type 2 diabetes

Replacement substance P reduces cardiac fibrosis in monkeys with type 2 diabetes

Background: Type 2 diabetes mellitus (T2DM)-associated cardiac fibrosis contributes to heart failure. We previously showed that diabetic mice with cardiomyopathy, including cardiac fibrosis, exhibit low levels of the neuropeptide substance P; exogenous replacement of substance P reversed cardiac fib...

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Bibliographic Details
Main Authors: Giselle C. Meléndez, Kylie Kavanagh, Nazli Gharraee, Jessica L. Lacy, Kevin H. Goslen, Masha Block, Jordyn Whitfield, Alexander Widiapradja, Scott P. Levick
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cardiomyopathy
Fibrosis
Heart
Non-human primate
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001531

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http://www.sciencedirect.com/science/article/pii/S0753332223001531

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