Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Clinical studies have shown that epileptic seizures worsen Alzheimer’s disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear. To assess the effects of seizures on the progression of AD, chronic temporal lobe epilepsy was induced in five familial AD mutat...

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Bibliographic Details
Main Authors: Yulian Zou, Chengyan Wang, Huang Li, Meihua Zhong, Jin Lin, Yan Hu, Zhou Chen, Chen-Ling Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
seizure
pentylenetetrazole
Alzheimer’s disease
DAPK
ERK
neuropathology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1500105/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1500105/full

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