REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

Summary: The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural prog...

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Bibliographic Details
Main Authors: Katharina Meyer, Heather M. Feldman, Tao Lu, Derek Drake, Elaine T. Lim, King-Hwa Ling, Nicholas A. Bishop, Ying Pan, Jinsoo Seo, Yuan-Ta Lin, Susan C. Su, George M. Church, Li-Huei Tsai, Bruce A. Yankner
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719300324

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http://www.sciencedirect.com/science/article/pii/S2211124719300324

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