Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition

Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition

Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese medicine, has been recommended to treat renal fibrosis for decades. Previous studies had shown that JPYSF could inhibit epithelial–mesenchymal transition (EMT), an important regulatory role in renal fibrosis. However, the mechanism of JPYSF acti...

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Bibliographic Details
Main Authors: Yuan Zhao, Xiangbin Li, Fochang Wang, Shiying Huang, Hanqian Du, Shunmin Li, Jianping Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
Jian-Pi-Yi-Shen formula
renal fibrosis
epithelial–mesenchymal transition
network pharmacology
Wnt3a/β-catenin signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.873023/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.873023/full

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