Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maint...

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Bibliographic Details
Main Authors: Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
Format: Article
Language:English
Published: Nature Portfolio 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14095

Internet

https://doi.org/10.1038/ncomms14095

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