Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maint...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14095 |
| _version_ | 1831771431861485568 |
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| author | Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali |
| author_facet | Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali |
| author_sort | Amy K. Rines |
| collection | DOAJ |
| description | The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice. |
| first_indexed | 2024-12-22T07:59:10Z |
| format | Article |
| id | doaj.art-bae6e26f24c34045be0fbe2c38eff574 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:59:10Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bae6e26f24c34045be0fbe2c38eff5742022-12-21T18:33:18ZengNature PortfolioNature Communications2041-17232017-01-018111310.1038/ncomms14095Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncouplingAmy K. Rines0Hsiang-Chun Chang1Rongxue Wu2Tatsuya Sato3Arineh Khechaduri4Hidemichi Kouzu5Jason Shapiro6Meng Shang7Michael A. Burke8Eltyeb Abdelwahid9Xinghang Jiang10Chunlei Chen11Tenley A. Rawlings12Gary D. Lopaschuk13Paul T. Schumacker14E. Dale Abel15Hossein Ardehali16Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityDivision of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah, School of MedicineCardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of AlbertaFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityDivision of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah, School of MedicineFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern UniversityThe Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.https://doi.org/10.1038/ncomms14095 |
| spellingShingle | Amy K. Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A. Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A. Rawlings Gary D. Lopaschuk Paul T. Schumacker E. Dale Abel Hossein Ardehali Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling Nature Communications |
| title | Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| title_full | Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| title_fullStr | Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| title_full_unstemmed | Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| title_short | Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| title_sort | snf1 related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling |
| url | https://doi.org/10.1038/ncomms14095 |
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