Advanced glycation end products induce Aβ1–42 deposition and cognitive decline through H19/miR-15b/BACE1 axis in diabetic encephalopathy

Advanced glycation end products induce Aβ1–42 deposition and cognitive decline through H19/miR-15b/BACE1 axis in diabetic encephalopathy

Objective: Diabetic encephalopathy (DE), a chronic complication of diabetes, is characterized by decline of cognitive function. The molecular mechanism of DE remains unclear. The purpose of this study is to evaluate the roles of advanced glycation end products (AGEs) in the pathogenesis of DE and in...

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Bibliographic Details
Main Authors: Lei Jiang, Nannan Yuan, Na Zhao, Pei Tian, Di Zhang, Yushi Qin, Zhongli Shi, Zhaoyu Gao, Nan Zhang, Huimin Zhou, Rui Zhang, Shunjiang Xu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain Research Bulletin
Subjects:
Diabetic encephalopathy
Advanced glycation end products (AGEs)
miR-15b
BACE1
Long non-coding RNA H19
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001988

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http://www.sciencedirect.com/science/article/pii/S0361923022001988

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