Intranasal Vaccination with rePcrV Protects against Pseudomonas aeruginosa and Generates Lung Tissue-Resident Memory T Cells

Tissue-resident memory T (TRM) cells are immune sentinels that bear a key role in the local immune system and rapidly respond to infection. Our previous studies showed that mucosal immunization via intranasal pathways was more effective than intramuscular route. However, the mechanism of enhanced pr...

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Bibliographic Details
Main Authors: Yangxue Ou, Ying Wang, Ting Yu, Zhiyuan Cui, Xin Chen, Weijun Zhang, Quanming Zou, Jiang Gu, Qianfei Zuo
Format: Article
Language:English
Published: Hindawi Limited 2022-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2022/1403788