Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Abstract Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain. In this study, we found that the hypothal...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-03-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-024-00316-w |