Molecular mechanism of the MORC4 ATPase activation

Human Microrchidia 4 (MORC4) ATPase has been implicated in acute and chronic pancreatitis, inflammatory disorders and cancer. Here the authors describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation.

Opis bibliograficzny
Główni autorzy: Adam H. Tencer, Khan L. Cox, Gregory M. Wright, Yi Zhang, Christopher J. Petell, Brianna J. Klein, Brian D. Strahl, Joshua C. Black, Michael G. Poirier, Tatiana G. Kutateladze
Format: Artykuł
Język:English
Wydane: Nature Portfolio 2020-10-01
Seria:Nature Communications
Dostęp online:https://doi.org/10.1038/s41467-020-19278-8