DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining

Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here, we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA ligase IV (LIG4); we show by single-molecule analys...

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Bibliographic Details
Main Authors: Michael P. Conlin, Dylan A. Reid, George W. Small, Howard H. Chang, Go Watanabe, Michael R. Lieber, Dale A. Ramsden, Eli Rothenberg
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
nonhomologous end joining
single molecule FRET
DNA repair
double strand break repair
DNA ligase IV
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312330

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http://www.sciencedirect.com/science/article/pii/S2211124717312330

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