Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells via promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the transcriptional regulator, AIRE. Whereas AIRE-expressing (Aire+) mTECs undergo constant turnover in the adult thym...

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Bibliographic Details
Main Authors: Takahisa Miyao, Maki Miyauchi, S Thomas Kelly, Tommy W Terooatea, Tatsuya Ishikawa, Eugene Oh, Sotaro Hirai, Kenta Horie, Yuki Takakura, Houko Ohki, Mio Hayama, Yuya Maruyama, Takao Seki, Hiroto Ishii, Haruka Yabukami, Masaki Yoshida, Azusa Inoue, Asako Sakaue-Sawano, Atsushi Miyawaki, Masafumi Muratani, Aki Minoda, Nobuko Akiyama, Taishin Akiyama
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
thymic epithelial cells
AIRE
differentiation
single-cell analysis
ATAC
transit-amplifying cells
Online Access:https://elifesciences.org/articles/73998

Internet

https://elifesciences.org/articles/73998

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