The Prognostic Effect of CDKN2A/2B Gene Deletions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM-Based Protocols

The Prognostic Effect of CDKN2A/2B Gene Deletions in Pediatric Acute Lymphoblastic Leukemia (ALL): Independent Prognostic Significance in BFM-Based Protocols

One of the most frequent genes affected in pediatric ALL is the CDKN2A/2B gene, acting as a secondary cooperating event and playing an important role in cell-cycle regulation and chemosensitivity. Despite its inclusion in combined CNA (copy-number alterations) classifiers, like the IKZF1plus entity...

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Bibliographic Details
Main Authors: Mirella Ampatzidou, Stefanos I. Papadhimitriou, Anna Paisiou, Georgios Paterakis, Marianna Tzanoudaki, Vassilios Papadakis, Lina Florentin, Sophia Polychronopoulou
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Diagnostics
Subjects:
acute lymphoblastic leukemia (ALL)
child
genetics
CDKN2A/2B deletions
fluorescent in situ hybridization (FISH)
multiple-ligation probe amplification (MLPA)
Online Access:https://www.mdpi.com/2075-4418/13/9/1589

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https://www.mdpi.com/2075-4418/13/9/1589

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