A non-replicative antibiotic resistance-free DNA vaccine delivered by the intranasal route protects against canine leishmaniasis

A non-replicative antibiotic resistance-free DNA vaccine delivered by the intranasal route protects against canine leishmaniasis

Leishmania infantum is the etiological agent of zoonotic visceral leishmaniasis (ZVL). The disease is endemic in Central and South America, Central and South East Asia, and the Mediterranean basin. Dogs are the main reservoir, with an estimated prevalence of approximately 2.5 million dogs in Souther...

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Bibliographic Details
Main Authors: Ana Alonso, Pedro José Alcolea, Jaime Larraga, María Paz Peris, Adriana Esteban, Alberto Cortés, Silvia Ruiz-García, Juan Antonio Castillo, Vicente Larraga
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
Leishmania infantum
canine leishmaniasis
LACK
third-generation vaccines
pPAL
protection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213193/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213193/full

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