Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions

Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions

The SARS-CoV-2 infection [coronavirus disease 2019 (COVID-19)] is associated with severe lymphopenia and impaired immune response, including expansion of myeloid cells with regulatory functions, e.g., so-called low-density neutrophils, containing granulocytic myeloid-derived suppressor cells (LDNs/P...

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Bibliographic Details
Main Authors: Izabela Siemińska, Kazimierz Węglarczyk, Marcin Surmiak, Dorota Kurowska-Baran, Marek Sanak, Maciej Siedlar, Jarek Baran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
COVID-19 convalescents
normal density neutrophils
immunosuppression
granulocyte-macrophage colony stimulating factor (GM-CSF)
low-density neutrophils (LDNs)
granulocytic myeloid-derived suppressor cells (PMN-MDSCs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.748097/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.748097/full

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