Evaluation of Some Safety Parameters of Dual Histamine H<sub>3</sub> and Sigma-2 Receptor Ligands with Anti-Obesity Potential

Evaluation of Some Safety Parameters of Dual Histamine H<sub>3</sub> and Sigma-2 Receptor Ligands with Anti-Obesity Potential

Many studies have shown the high efficacy of histamine H<sub>3</sub> receptor ligands in preventing weight gain. In addition to evaluating the efficacy of future drug candidates, it is very important to assess their safety profile, which is established through numerous tests and preclini...

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Bibliographic Details
Main Authors: Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Agata Siwek, Katarzyna Szczepańska, Katarzyna Kieć-Kononowicz, Magdalena Kotańska
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
histamine H<sub>3</sub> receptor antagonists
sigma-2 receptor ligands
obesity
safety
hERG
locomotor activity
Online Access:https://www.mdpi.com/1422-0067/24/8/7499

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https://www.mdpi.com/1422-0067/24/8/7499

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