TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet

TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet

Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2+]ER) release, both of which are regulated by the t...

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Bibliographic Details
Main Authors: Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000019

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http://www.sciencedirect.com/science/article/pii/S2211124724000019

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