Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

IntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and ide...

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Bibliographic Details
Main Authors: Seyed M. Ghiasi, Piero Marchetti, Lorenzo Piemonti, Jens H. Nielsen, Bo T. Porse, Thomas Mandrup-Poulsen, Guy A. Rutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Endocrinology
Subjects:
β-cells
insulin secretion
transcript
nonsense-mediated decay
RNA decay
RNA processing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1359147/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1359147/full

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