NMF-Based Approach for Missing Values Imputation of Mass Spectrometry Metabolomics Data

NMF-Based Approach for Missing Values Imputation of Mass Spectrometry Metabolomics Data

In mass spectrometry (MS)-based metabolomics, missing values (NAs) may be due to different causes, including sample heterogeneity, ion suppression, spectral overlap, inappropriate data processing, and instrumental errors. Although a number of methodologies have been applied to handle NAs, NA imputat...

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Bibliographic Details
Main Authors: Jingjing Xu, Yuanshan Wang, Xiangnan Xu, Kian-Kai Cheng, Daniel Raftery, Jiyang Dong
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
non-negative matrix factorization
missing values imputation
mass spectrometry
metabolomics data
missing pattern
outliers
Online Access:https://www.mdpi.com/1420-3049/26/19/5787

Internet

https://www.mdpi.com/1420-3049/26/19/5787

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