Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Objective: In this study, small molecules possessing tetrahydropyrimidine derivatives have been synthesized having halogenated benzyl derivatives and carboxylate linkage. As previously reported, FDA approved halogenated pyrimidine derivatives prompted us to synthesize novel compounds in order to eva...

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Bibliographic Details
Main Authors: Uzma Arshad, Sibtain Ahmed, Nusrat Shafiq, Zaheer Ahmad, Aqsa Hassan, Naseem Akhtar, Shagufta Parveen, Tahir Mehmood
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
pyrimidine
solvent less
in silico
in vitro
QSAR
DFT
Online Access:https://www.mdpi.com/1420-3049/26/15/4424

Internet

https://www.mdpi.com/1420-3049/26/15/4424

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