Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment

Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment

Mitochondrial bioenergetics profiling, a measure of oxygen consumption rates, correlates with prognostic markers and can be used to assess response to therapy in chronic lymphocytic leukemia (CLL) cells. In this study, we measured mitochondrial respiration rates in primary CLL cells using respiromet...

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Bibliographic Details
Main Authors: Subir Roy Chowdhury, Eric D. J. Bouchard, Ryan Saleh, Zoann Nugent, Cheryl Peltier, Edgard Mejia, Sen Hou, Carly McFall, Mandy Squires, Donna Hewitt, Linda Davidson, Garry X. Shen, James B. Johnston, Christine Doucette, Grant M. Hatch, Paul Fernyhough, Aaron Marshall, Spencer B. Gibson, David E. Dawe, Versha Banerji
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
chronic lymphocytic leukemia
mitochondria
oxygen consumption rates
oroboros oxygraph
zap-70
b cell receptor
ibrutinib
ccl3/ccl4
Online Access:https://www.mdpi.com/2072-6694/12/3/650

Internet

https://www.mdpi.com/2072-6694/12/3/650

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