IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation

IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation

Abstract Background Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. Methods In the present study, wild-type (WT) and IL-33−/− mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuro...

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Bibliographic Details
Main Authors: Kelei Cao, Xiang Liao, Jiahui Lu, Shu Yao, Fengjiao Wu, Xingxing Zhu, Dongyan Shi, Shuang Wen, Lixin Liu, Hong Zhou
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
CNS inflammation
IL-33/ST2
Neutrophil infiltration
Endothelial activation
Microglia activation
Intravital microscopy
Online Access:http://link.springer.com/article/10.1186/s12974-018-1169-6

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http://link.springer.com/article/10.1186/s12974-018-1169-6

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