Di-(2-ethylhexyl) Phthalate Limits the Lipid-Lowering Effects of Simvastatin by Promoting Protein Degradation of Low-Density Lipoprotein Receptor: Role of PPARγ-PCSK9 and LXRα-IDOL Signaling Pathways

Di-(2-ethylhexyl) Phthalate Limits the Lipid-Lowering Effects of Simvastatin by Promoting Protein Degradation of Low-Density Lipoprotein Receptor: Role of PPARγ-PCSK9 and LXRα-IDOL Signaling Pathways

Dialysis prevents death from uremia in patients with end-stage renal disease (ESRD). Nevertheless, during hemodialysis, circulating levels of di-(2-ethylhexyl) phthalate (DEHP) are increased due to phthalates leaching from medical tubes. Statins are an effective therapy for reducing the risks associ...

Full description

Bibliographic Details
Main Authors: Bei-Chia Guo, Ko-Lin Kuo, Jenq-Wen Huang, Chia-Hui Chen, Der-Cherng Tarng, Tzong-Shyuan Lee
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
di-(2-ethylhexyl) phthalate
statin
low-density lipoprotein receptor
reactive oxygen species
transient receptor potential ankyrin 1
peroxisome proliferator-activated receptor γ
Online Access:https://www.mdpi.com/2076-3921/12/2/477

Internet

https://www.mdpi.com/2076-3921/12/2/477

Similar Items