Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression

Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression

Liver fibrosis can occur in many chronic liver diseases, and no effective treatments are available due to the poorly characterized molecular pathogenesis. Semaphorin 4D (Sema4D) has immune functions and serves important roles in T cell priming. Here, we found that Sema4D was highly expressed in fibr...

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Bibliographic Details
Main Authors: Lifu Wang, Dinghao Li, Zifeng Zhu, Yao Liao, Ji Wu, Yuheng Liu, Ruibing Yang, Hanqiao Dai, Zhongdao Wu, Xi Sun
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Pharmacological Research
Subjects:
Liver fibrosis
Semaphorin 4D
Retinol metabolism
AOX1
Retinoic acid receptor α
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002426

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http://www.sciencedirect.com/science/article/pii/S1043661823002426

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