Use of Next-Generation Sequencing for Identifying Mitochondrial Disorders

Use of Next-Generation Sequencing for Identifying Mitochondrial Disorders

Mitochondria are major contributors to ATP synthesis, generating more than 90% of the total cellular energy production through oxidative phosphorylation (OXPHOS): metabolite oxidation, such as the β-oxidation of fatty acids, and the Krebs’s cycle. OXPHOS inadequacy due to large genetic lesions in mi...

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Bibliographic Details
Main Authors: Shafi Mahmud, Suvro Biswas, Shamima Afrose, Mohasana Akter Mita, Md. Robiul Hasan, Mst. Sharmin Sultana Shimu, Gobindo Kumar Paul, Sanghyun Chung, Md. Abu Saleh, Sultan Alshehri, Momammed M. Ghoneim, Maha Alruwaily, Bonglee Kim
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Current Issues in Molecular Biology
Subjects:
mitochondrial disorder
OXPHOS
mtDNA
nDNA
NGS
Online Access:https://www.mdpi.com/1467-3045/44/3/74

Internet

https://www.mdpi.com/1467-3045/44/3/74

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