The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression

The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression

Abstract Background The FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting the FGF/FGFR pathway, in epithelial ovarian cancer (EOC) and strategies on overcoming AZD4547 resistance. Methods The effect of AZD4547 on c...

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Bibliographic Details
Main Authors: Yoo-Young Lee, Ji-Yoon Ryu, Young-Jae Cho, Ju-Yeon Choi, Jung-Joo Choi, Chel Hun Choi, Jason K. Sa, Jae Ryoung Hwang, Jeong-Won Lee
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Epithelial ovarian cancer
AZD4547
c-Met
FGF19
FGFR4
Patient-derived xenograft
Online Access:https://doi.org/10.1186/s12935-024-03235-2

Internet

https://doi.org/10.1186/s12935-024-03235-2

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