In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral Treatments

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral Treatments

Here, we report the in-host hepatitis E virus (HEV) quasispecies evolution in a chronically infected patient who was treated with three different regimens of ribavirin (RBV) for nearly 6 years. Sequential plasma samples were collected at different time points and subjected to RNA extraction and deep...

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Bibliographic Details
Main Authors: Sergi Colomer-Castell, Josep Gregori, Damir Garcia-Cehic, Mar Riveiro-Barciela, Maria Buti, Ariadna Rando-Segura, Judit Vico-Romero, Carolina Campos, Marta Ibañez-Lligoña, Caroline Melanie Adombi, Maria Francesca Cortese, David Tabernero, Juan Ignacio Esteban, Francisco Rodriguez-Frias, Josep Quer
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
quasispecies
deep sequencing
variability
rare haplotypes
fitness
mutagens
Online Access:https://www.mdpi.com/1422-0067/24/24/17185

Internet

https://www.mdpi.com/1422-0067/24/24/17185

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