Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma

Children diagnosed with endemic Burkitt lymphoma (eBL) are deficient in interferon-γ (IFN-γ) responses to Epstein–Barr Nuclear Antigen1 (EBNA1), the viral protein that defines the latency I pattern in this B cell tumor. However, the contributions of immune-regulatory cytokines and phenotypes of the...

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Bibliographic Details
Main Authors: Catherine S. Forconi, David H. Mulama, Priya Saikumar Lakshmi, Joslyn Foley, Juliana A. Otieno, Jonathan D. Kurtis, Leslie J. Berg, John M. Ong’echa, Christian Münz, Ann M. Moormann
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
endemic Burkitt lymphoma
EBV
T-cells
EBNA1
cytokines
PD-1
Online Access:https://www.mdpi.com/2072-6694/13/21/5375

Internet

https://www.mdpi.com/2072-6694/13/21/5375

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