Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer
The expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE<sub>2</sub> plays an important role in angiogenesis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
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The Editorial Department of Chinese Journal of Clinical Research
2023-09-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230912&flag=1 |
| _version_ | 1827808068902060032 |
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| author | ZHENG Lirong DU Haoyang ZHANG Ruifen ZHANG Hairong BAO Aruhan YU Lei CUI Hongwei |
| author_facet | ZHENG Lirong DU Haoyang ZHANG Ruifen ZHANG Hairong BAO Aruhan YU Lei CUI Hongwei |
| author_sort | ZHENG Lirong |
| collection | DOAJ |
| description | The expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE<sub>2</sub> plays an important role in angiogenesis, survival, invasion and migration of colon cancer cells. The EP<sub>4</sub> receptor, as an important transporter of PGE<sub>2</sub> signaling, increases the survival and development of colon cancer cells through various mechanisms of overexpression. Signal pathway starting from COX-2, continuing with PGE<sub>2</sub> and ending with EP<sub>4</sub> can promote the spread and growth of colon cancer. Therefore, targeting the COX-2/PGE<sub>2</sub>/EP<sub>4</sub> axis may be a valuable treatment method for colon cancer. This article outlines the biological activity of COX-2, the mechanism of action of COX-2/PGE<sub>2</sub>/EP<sub>4</sub> as a signal axis in colon cancer, and the research progress of targeted drugs in colon cancer prevention.
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| first_indexed | 2024-03-11T22:06:12Z |
| format | Article |
| id | doaj.art-bb123b6c8ad843e1ad543faad28d2b41 |
| institution | Directory Open Access Journal |
| issn | 1674-8182 |
| language | zho |
| last_indexed | 2024-03-11T22:06:12Z |
| publishDate | 2023-09-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj.art-bb123b6c8ad843e1ad543faad28d2b412023-09-25T05:42:08ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822023-09-0136913381341,134710.13429/j.cnki.cjcr.2023.09.012Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancerZHENG Lirong0DU Haoyang1ZHANG Ruifen2ZHANG Hairong3BAO Aruhan4YU Lei5CUI Hongwei6Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, ChinaInner Mongolia Medical University, Hohhot, Inner Mongolia 010110, ChinaInner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010000, ChinaInner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010000, ChinaInner Mongolia Medical University, Hohhot, Inner Mongolia 010110, ChinaInner Mongolia Medical University, Hohhot, Inner Mongolia 010110, ChinaPeking University Oncology Hospital Inner Mongolia Hospital Inner Mongolia Medical University Affiliated Oncology Hospital, Hohhot, Inner Mongolia 010020, ChinaThe expression of cyclooxygenase 2 (COX-2) was up-regulated and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) was significantly increased in colon cancer patients. As the main prostaglandin produced by COX-2, PGE<sub>2</sub> plays an important role in angiogenesis, survival, invasion and migration of colon cancer cells. The EP<sub>4</sub> receptor, as an important transporter of PGE<sub>2</sub> signaling, increases the survival and development of colon cancer cells through various mechanisms of overexpression. Signal pathway starting from COX-2, continuing with PGE<sub>2</sub> and ending with EP<sub>4</sub> can promote the spread and growth of colon cancer. Therefore, targeting the COX-2/PGE<sub>2</sub>/EP<sub>4</sub> axis may be a valuable treatment method for colon cancer. This article outlines the biological activity of COX-2, the mechanism of action of COX-2/PGE<sub>2</sub>/EP<sub>4</sub> as a signal axis in colon cancer, and the research progress of targeted drugs in colon cancer prevention. http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230912&flag=1cyclooxygenase 2prostaglandin e<sub>2</sub>ep<sub>4</sub> receptorcolon cancer; aspirin; celecoxib |
| spellingShingle | ZHENG Lirong DU Haoyang ZHANG Ruifen ZHANG Hairong BAO Aruhan YU Lei CUI Hongwei Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer Zhongguo linchuang yanjiu cyclooxygenase 2 prostaglandin e<sub>2</sub> ep<sub>4</sub> receptor colon cancer; aspirin; celecoxib |
| title | Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer |
| title_full | Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer |
| title_fullStr | Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer |
| title_full_unstemmed | Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer |
| title_short | Research progress on COX-2/PGE<sub>2</sub>/EP<sub>4</sub> signaling axis in colon cancer |
| title_sort | research progress on cox 2 pge sub 2 sub ep sub 4 sub signaling axis in colon cancer |
| topic | cyclooxygenase 2 prostaglandin e<sub>2</sub> ep<sub>4</sub> receptor colon cancer; aspirin; celecoxib |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230912&flag=1 |
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