The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas

The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas

Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH adenomas (SCA), Crooke cell adenomas (CCA) and ACTH-producing carcinomas (CA). The molecular pathogenesis of these tumors is still poor...

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Bibliographic Details
Main Authors: Sergio Andonegui-Elguera, Gloria Silva-Román, Eduardo Peña-Martínez, Keiko Taniguchi-Ponciano, Sandra Vela-Patiño, Ilan Remba-Shapiro, Erick Gómez-Apo, Ana-Laura Espinosa-de-los-Monteros, Lesly A. Portocarrero-Ortiz, Gerardo Guinto, Sergio Moreno-Jimenez, Laura Chavez-Macias, Renata Saucedo, Lourdes Basurto-Acevedo, Blas Lopez-Felix, Carolina Gonzalez-Torres, Javier Gaytan-Cervantes, Jorge T. Ayala-Sumuano, Andres Burak-Leipuner, Daniel Marrero-Rodríguez, Moisés Mercado
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
corticotroph
Cushing disease
ACTH-secreting carcinoma
single nucleotide variation
copy number variation
exome
Online Access:https://www.mdpi.com/1422-0067/23/9/4861

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https://www.mdpi.com/1422-0067/23/9/4861

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