Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats

Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats

Abstract Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and cartilage damage. Intra-articular (i.a) viscosupplementation with hyaluronic acid (HA) is frequently used for the management of OA. Preclinical studies have reported that bisphosphonates (BPs) may have a t...

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Bibliographic Details
Main Authors: Anna Scanu, Roberto Luisetto, Mauro Pavan, Cristian Guarise, Riccardo Beninatto, Chiara Giraudo, Francesca Galuppini, Vanni Lazzarin, Vincenza Guzzardo, Gianmaria Pennelli, Devis Galesso, Stefano Masiero
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46965-5

Internet

https://doi.org/10.1038/s41598-023-46965-5

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