Comparison between Nanoparticle Encapsulation and Surface Loading for Lysosomal Enzyme Replacement Therapy

Comparison between Nanoparticle Encapsulation and Surface Loading for Lysosomal Enzyme Replacement Therapy

Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) enhance the delivery of therapeutic enzymes for replacement therapy of lysosomal storage disorders. Previous studies examined NPs encapsulating or coated with enzymes, but these formulations have never been compared. We examined this using hyalur...

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Bibliographic Details
Main Authors: Eameema Muntimadugu, Marcelle Silva-Abreu, Guillem Vives, Maximilian Loeck, Vy Pham, Maria del Moral, Melani Solomon, Silvia Muro
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
enzyme therapeutics
poly(lactic-co-glycolic acid) nanoparticles
encapsulation
surface loading
ICAM-1 targeting
lysosomal delivery
Online Access:https://www.mdpi.com/1422-0067/23/7/4034

Internet

https://www.mdpi.com/1422-0067/23/7/4034

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