Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

The ribosomal protein S6 kinase beta 2 (S6K2) is thought to play an important role in malignant cell proliferation, but is understudied compared to its closely related homolog S6 kinase beta 1 (S6K1). To better understand the biological function of S6K2, chemical probes are needed, but the high simi...

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Bibliographic Details
Main Authors: Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin P. Schwalm, Valentin Wydra, Ricardo A. M. Serafim, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
protein kinases
chemical probes
S6K2
p70S6K2
p70S6Kb
RPS6KB2
Online Access:https://www.mdpi.com/2072-6694/13/20/5133

Internet

https://www.mdpi.com/2072-6694/13/20/5133

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