ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

Summary: While ATM loss of function has long been identified as the genetic cause of ataxia-telangiectasia (A-T), how it leads to selective and progressive degeneration of cerebellar Purkinje and granule neurons remains unclear. ATM expression is enriched in microglia throughout cerebellar developme...

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Bibliographic Details
Main Authors: Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie Tolles, Junseok Park, Thomas W. Chittenden, Patrick G. Buckley, Timothy W. Yu, Michael A. Lodato, Eunjung Alice Lee
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016340

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http://www.sciencedirect.com/science/article/pii/S2211124723016340

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