Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence

Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence

ABSTRACT Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vac...

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Bibliographic Details
Main Authors: Emiliano Chiarot, Cristina Faralla, Nico Chiappini, Giovanna Tuscano, Fabiana Falugi, Gabriella Gambellini, Annarita Taddei, Sabrina Capo, Elena Cartocci, Daniele Veggi, Alessia Corrado, Simona Mangiavacchi, Simona Tavarini, Maria Scarselli, Robert Janulczyk, Guido Grandi, Immaculada Margarit, Giuliano Bensi
Format: Article
Language:English
Published: American Society for Microbiology 2013-03-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00387-12

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https://journals.asm.org/doi/10.1128/mBio.00387-12

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