Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

Frontotemporal dementia (FTD) is an early onset neurodegenerative disease. Mutations in several genes cause familial FTD and one of them is charged multivesicular body protein 2B (CHMP2B) on chromosome 3 (FTD3), a component of the endosomal sorting complex required for transport III (ESCRT-III). We...

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Bibliographic Details
Main Authors: Yu Zhang, Benjamin Schmid, Troels T. Nielsen, Jørgen E. Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst, Kristine K. Freude
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300678

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http://www.sciencedirect.com/science/article/pii/S1873506116300678

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