Clinical implications of neoepitope landscapes for adult and pediatric cancers

Clinical implications of neoepitope landscapes for adult and pediatric cancers

Abstract Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly highe...

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Bibliographic Details
Main Authors: Yang-Yang Feng, Obi L. Griffith, Malachi Griffith
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Medicine
Subjects:
Exome sequencing
Immunotherapy
Neoepitope
Personalized cancer vaccine
RNA sequencing
Whole-genome sequencing
Online Access:http://link.springer.com/article/10.1186/s13073-017-0470-9

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http://link.springer.com/article/10.1186/s13073-017-0470-9

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