Hide and Seek: The Game Between Chronic Lymphocytic Leukaemia Cells and B Cell Receptor Signalling Inhibitors

Hide and Seek: The Game Between Chronic Lymphocytic Leukaemia Cells and B Cell Receptor Signalling Inhibitors

The emergence of B cell receptor (BCR) kinase inhibitors has recently changed the treatment landscape in chronic lymphocytic leukaemia (CLL). The inhibitors that selectively target potential kinases downstream from BCR (particularly Bruton’s tyrosine kinase [BTK] and phosphoinositide 3-kinase [PI3K]...

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Bibliographic Details
Main Authors: Kumudha Balakrishnan, Krishna Bojja, William Decker, Michael J. Keating
Format: Article
Language:English
Published: European Medical Journal 2017-03-01
Series:European Medical Journal
Subjects:
chronic lymphocytic leukaemia (cll)
phosphoinositide 3-kinase (pi3k)
duvelisib (ipi-145)
apoptosis
b cell receptor (bcr)
microenvironment
bcr inhibitors
ibrutinib
idelalisib
Online Access:https://www.emjreviews.com/hematology/article/hide-and-seek-the-game-between-chronic-lymphocytic-leukaemia-cells-and-b-cell-receptor-signalling-inhibitors/

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https://www.emjreviews.com/hematology/article/hide-and-seek-the-game-between-chronic-lymphocytic-leukaemia-cells-and-b-cell-receptor-signalling-inhibitors/

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