Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

Highlights Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formation Protrusion formation of MCF10A-derived and primary murine acini is MRTF-dependent Genetic MRTF-A activation in primary organoids...

Full description

Bibliographic Details
Main Authors: Marie-Luise Melcher, Ines Block, Karolin Kropf, Anurag Kumar Singh, Guido Posern
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
Mrtf
Mammary acini
Mechanotransduction
Stiffness
Protrusion formation
Online Access:https://doi.org/10.1186/s12964-022-00977-2

Internet

https://doi.org/10.1186/s12964-022-00977-2

Similar Items