Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation
Highlights Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formation Protrusion formation of MCF10A-derived and primary murine acini is MRTF-dependent Genetic MRTF-A activation in primary organoids...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-00977-2 |