Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

Alzheimer's disease (AD) is a neurodegenerative disorder strongly associates with aging. While amyloid plagues and neurofibrillary tangles are pathological hallmarks of AD, recent evidence suggests synaptic dysfunction and physical loss may be the key mechanisms that determine the clinical synd...

Full description

Bibliographic Details
Main Authors: Jing Wei, Xiaokuang Ma, Antoine Nehme, Yuehua Cui, Le Zhang, Shenfeng Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
MET receptor tyrosine kinase
hepatocyte growth factor
synaptic plasticity
regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.954266/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.954266/full

Similar Items