Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model

Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model

Schizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo 2-photon calcium imaging a...

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Bibliographic Details
Main Authors: Chunhua Zhou, Dezhi Kong, Xiaodong Zhu, Wei Wu, Rong Xue, Gongying Li, Yong Xu, Sha Liu, Hongjun Tian, Chuanjun Zhuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
schizophrenia
depression
mouse model
behavioral phenotypes
prefrontal cortex neuronal activity
antipsychotic treatment
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00115/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00115/full

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