Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model
Schizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo 2-photon calcium imaging a...
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| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00115/full |
| _version_ | 1819265801283174400 |
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| author | Chunhua Zhou Dezhi Kong Xiaodong Zhu Wei Wu Rong Xue Gongying Li Yong Xu Sha Liu Hongjun Tian Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo |
| author_facet | Chunhua Zhou Dezhi Kong Xiaodong Zhu Wei Wu Rong Xue Gongying Li Yong Xu Sha Liu Hongjun Tian Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo |
| author_sort | Chunhua Zhou |
| collection | DOAJ |
| description | Schizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo 2-photon calcium imaging and electrophysiological recordings were performed in conjunction with behavioral phenotyping. Compared to mice models with classical depression or to schizophrenia models, the animal models with schizophrenia and depression comorbidity presented worse psychotic and depressive symptoms. These behavioral deficits are associated with impaired neuronal calcium activities in the frontal cortex and thalamic nuclei. Moreover, in sharp contrast to classical models that have a satisfactory response to antipsychotic or antidepressant drugs, this novel schizophrenia with depression model is resilient to combined drug treatment in terms of behavioral and functional recovery. Taken together, these data indicate that schizophrenia with depression likely involves a unique pathophysiology that is different from schizophrenia or depression alone. |
| first_indexed | 2024-12-23T20:51:09Z |
| format | Article |
| id | doaj.art-bb426ffc5dd3462fb3e063298a3065a0 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-23T20:51:09Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-bb426ffc5dd3462fb3e063298a3065a02022-12-21T17:31:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-03-011410.3389/fnins.2020.00115507656Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse ModelChunhua Zhou0Dezhi Kong1Xiaodong Zhu2Wei Wu3Rong Xue4Gongying Li5Yong Xu6Sha Liu7Hongjun Tian8Chuanjun Zhuo9Chuanjun Zhuo10Chuanjun Zhuo11Department of Pharmacology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaTwo-Photon In Vivo Imaging Centre, Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, ChinaTianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaInstitute of Brain Micro Scale Imaging Centre, School of Mental Health, Jining Medical University, Jining, ChinaMDT Center for Cognitive Impairment and Sleep Disorders, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaMDT Center for Cognitive Impairment and Sleep Disorders, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaPsychiatric-Neuroimaging-Genetics-Comorbidity Laboratory (PNGC_Lab), Tianjin Mental Health Centre, Mental Health Teaching Hospital of Tianjin Medical University, Tianjin Anding Hospital, Tianjin, ChinaInstitute of Brain Micro Scale Imaging Centre, School of Mental Health, Jining Medical University, Jining, ChinaMDT Center for Cognitive Impairment and Sleep Disorders, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaPsychiatric-Neuroimaging-Genetics-Comorbidity Laboratory (PNGC_Lab), Tianjin Mental Health Centre, Mental Health Teaching Hospital of Tianjin Medical University, Tianjin Anding Hospital, Tianjin, ChinaSchizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo 2-photon calcium imaging and electrophysiological recordings were performed in conjunction with behavioral phenotyping. Compared to mice models with classical depression or to schizophrenia models, the animal models with schizophrenia and depression comorbidity presented worse psychotic and depressive symptoms. These behavioral deficits are associated with impaired neuronal calcium activities in the frontal cortex and thalamic nuclei. Moreover, in sharp contrast to classical models that have a satisfactory response to antipsychotic or antidepressant drugs, this novel schizophrenia with depression model is resilient to combined drug treatment in terms of behavioral and functional recovery. Taken together, these data indicate that schizophrenia with depression likely involves a unique pathophysiology that is different from schizophrenia or depression alone.https://www.frontiersin.org/article/10.3389/fnins.2020.00115/fullschizophreniadepressionmouse modelbehavioral phenotypesprefrontal cortex neuronal activityantipsychotic treatment |
| spellingShingle | Chunhua Zhou Dezhi Kong Xiaodong Zhu Wei Wu Rong Xue Gongying Li Yong Xu Sha Liu Hongjun Tian Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model Frontiers in Neuroscience schizophrenia depression mouse model behavioral phenotypes prefrontal cortex neuronal activity antipsychotic treatment |
| title | Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model |
| title_full | Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model |
| title_fullStr | Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model |
| title_full_unstemmed | Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model |
| title_short | Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model |
| title_sort | rethinking schizophrenia and depression comorbidity as one psychiatric disorder entity evidence from mouse model |
| topic | schizophrenia depression mouse model behavioral phenotypes prefrontal cortex neuronal activity antipsychotic treatment |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00115/full |
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