OSMI-1 Enhances TRAIL-Induced Apoptosis through ER Stress and NF-κB Signaling in Colon Cancer Cells

OSMI-1 Enhances TRAIL-Induced Apoptosis through ER Stress and NF-κB Signaling in Colon Cancer Cells

Levels of O-GlcNAc transferase (OGT) and hyper-O-GlcNAcylation expression levels are associated with cancer pathogenesis. This study aimed to find conditions that maximize the therapeutic effect of cancer and minimize tissue damage by combining an OGT inhibitor (OSMI-1) and tumor necrosis factor-rel...

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Bibliographic Details
Main Authors: Su-Jin Lee, Da-Eun Lee, Soo-Young Choi, Oh-Shin Kwon
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
O-GlcNAc transferase inhibitor
TRAIL
apoptosis
ER stress
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/20/11073

Internet

https://www.mdpi.com/1422-0067/22/20/11073

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