High Titer Persistent Neutralizing Antibodies Induced by TSST-1 Variant Vaccine Against Toxic Shock Cytokine Storm

High Titer Persistent Neutralizing Antibodies Induced by TSST-1 Variant Vaccine Against Toxic Shock Cytokine Storm

Staphylococcal superantigen toxins lead to a devastating cytokine storm resulting in shock and multi-organ failure. We have previously assessed the safety and immunogenicity of a recombinant toxic shock syndrome toxin 1 variant vaccine (rTSST-1v) in clinical trials (NCT02971670 and NCT02340338). The...

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Bibliographic Details
Main Authors: Andreas Roetzer, Norbert Stich, Nina Model, Michael Schwameis, Christa Firbas, Bernd Jilma, Martha M. Eibl
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Toxins
Subjects:
Staphylococcus
toxic shock syndrome
neutralizing antibodies
immunogenicity
Online Access:https://www.mdpi.com/2072-6651/12/10/640

Internet

https://www.mdpi.com/2072-6651/12/10/640

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