Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis

Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis

Abstract The mechanism of hypoxia in chemoresistance of pancreatic ductal adenocarcinoma (PDAC) remains elusive. In this study, we revealed the essential role of miR-485-3p in PDAC, particularly its impact on cancer stemness and gemcitabine resistance under hypoxic conditions. We found substantial d...

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Bibliographic Details
Main Authors: Xinxin Liu, Zhihua Huang, Qiuzheng Chen, Kai Chen, Weikang Liu, Guangnian Liu, Xiangyu Chu, Dongqi Li, Yongsu Ma, Xiaodong Tian, Yinmo Yang
Format: Article
Language:English
Published: Nature Publishing Group 2024-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02035-x

Internet

https://doi.org/10.1038/s41420-024-02035-x

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