Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization

Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization

The production of cell-type– and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)–mediated cell-type– and age-specific recombination in floxed mice. To achiev...

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Bibliographic Details
Main Authors: Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hirokazu Hirai
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
PHP.eB
AAV-F
glial fibrillary acidic protein
astrocyte
floxed mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124000019

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http://www.sciencedirect.com/science/article/pii/S2329050124000019

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