Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

<p>Abstract</p> <p>Background</p> <p>DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Phase I clinical trial usi...

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Bibliographic Details
Main Authors: Piperno Sophie, Movassagh Mojgan, Dhellin Olivier, Bonnerot Christian, Boccaccio Catherine, Amigorena Sebastian, Borg Christophe, Leboulaire Christophe, Flament Caroline, Novault Sophie, Caby Marie-Pierre, André Fabrice, Chaput Nathalie, Dorval Thierry, Escudier Bernard, Robert Caroline, Serra Vincent, Valente Nancy, Le Pecq Jean-Bernard, Spatz Alain, Lantz Olivier, Tursz Thomas, Angevin Eric, Zitvogel Laurence
Format: Article
Language:English
Published: BMC 2005-03-01
Series:Journal of Translational Medicine
Subjects:
exosomes
dendritic cells
phase I trial
cancer vaccine
immunotherapy
Online Access:http://www.translational-medicine.com/content/3/1/10

Internet

http://www.translational-medicine.com/content/3/1/10

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