A Practical and Economical Route to (S)-Glycidyl Pivalate

A Practical and Economical Route to (S)-Glycidyl Pivalate

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Bibliographic Details
Main Authors: Jeffrey M. Noble, Le Chang, Dan Chen, Binglin Wang, Raymond N. Dominey, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham, Flavio S. P. Cardoso, David R. Snead
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-10-01
Series:SynOpen
Subjects:
tuberculosis
api
pretomanid
epichlorohydrin
supply centered synthesis
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751375

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751375

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