Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Abstract Recently, moderate prenatal alcohol exposure (PAE) was shown to be a risk factor for peripheral neuropathy following minor nerve injury. This effect coincides with elevated spinal cord astrocyte activation and ex vivo immune cell reactivity assessed by proinflammatory cytokine interleukin (...

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Bibliographic Details
Main Authors: Joshua J. Sanchez, Jacob E. Sanchez, Shahani Noor, Chaselyn D. Ruffaner-Hanson, Suzy Davies, Carston R. Wagner, Lauren L. Jantzie, Nikolaos Mellios, Daniel D. Savage, Erin D. Milligan
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
Neuropathic pain
Prenatal alcohol exposure
Glia
Neuroimmune function
Peripheral immune system
Spinal cord
Online Access:http://link.springer.com/article/10.1186/s40478-019-0701-y

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http://link.springer.com/article/10.1186/s40478-019-0701-y

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