Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohortResearch in context

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohortResearch in context

Summary: Background: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS). Methods: A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from CARTaG...

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Bibliographic Details
Main Authors: Véronique Boumtje, Hasanga D. Manikpurage, Zhonglin Li, Nathalie Gaudreault, Victoria Saavedra Armero, Dominique K. Boudreau, Sébastien Renaut, Cyndi Henry, Christine Racine, Aida Eslami, Stéphanie Bougeard, Evelyne Vigneau, Mathieu Morissette, Benoit J. Arsenault, Catherine Labbé, Anne-Sophie Laliberté, Simon Martel, François Maltais, Christian Couture, Patrice Desmeules, Patrick Mathieu, Sébastien Thériault, Philippe Joubert, Yohan Bossé
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:EBioMedicine
Subjects:
Lung cancer
Polygenic risk score
Genetic risk
Smoking
GWAS
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642400269X

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http://www.sciencedirect.com/science/article/pii/S235239642400269X

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